Russel Wallace : Alfred Russell Wallace (sic)
(1) In the first place they are interested parties, both pecuniarily and in a much greater degree on account of professional training and prestige. Only three years after vaccination was first introduced, on the recommendation of the heads of the profession, and their expressed conviction that it would give lifelong protection against a terrible disease, Parliament voted Jenner £10,000 in 1802, and £20,000 more in 1807, besides endowing vaccination with £3,000 a year in 1808. From that time doctors as a body were committed to its support; it has been taught for nearly a century as an almost infallible remedy in all our medical schools; and has been for the most part accepted by the public and the legislature as if it were a well-established scientific principle, instead of being as the historian of epidemic diseases--Dr. Creighton--well terms it, a grotesque superstition.
(2) Whether vaccination produces good or bad results can only be determined by its effects on a large scale. We must see whether, during epidemics [[p. 4]] --at different periods or in different places--small-pox mortality is diminished as compared with that from other diseases in proportion to the total amount of vaccination; and this can be done only by the Statistician, using the best materials--in this country those of our Registrar-Generals.
Two of the greatest medical authorities on vaccination,
Sir John Simon and Dr. Guy, F.R.S., have declared this to be necessary.
The former, in 1857, in a Parliamentary Report on the History and
Practice of Vaccination, says: "From individual cases the appeal
is to masses of national experience." Dr. Guy, in a celebrated
paper published by the Royal Statistical Society, says: "Is vaccination
a preventive of small-pox? To this question there is, there can be,
no answer except such as is couched in the language of figures." The
language of figures is "Statistics"; hence, statisticians, not doctors,
are the only good judges of this question. But the last Royal Commission
consisted wholly of doctors, lawyers, politicians and country gentlemen,
not one trained statistician! Hence, as I have demonstrated in my Vaccination
a Delusion, they have made the grossest blunders and their Report
is absolutely worthless.
[[p. 5]] II. What is Proved by the Best Statistical Evidence Available.
(1) The only complete and trustworthy records of mortality and of the causes of death which we possess, are those of the Registrar-Generals for England and Wales, for Scotland and for Ireland; the former from 1838, the two latter from later dates. But for London we have records from a much earlier period--the Bills of Mortality, which, though not completely accurate, are yet considered to show the rise and fall of the death-rates from the chief diseases then recognised, with sufficient general accuracy to be very valuable. They are continually appealed to in order to show the enormous improvement in the health of London in the nineteenth as compared with the eighteenth century, and this comparison as regards small-pox is one of the stock arguments of the doctors, and was strongly urged by the Royal Commissioners. It is stated over and over again that, down to the year 1800, small-pox deaths were excessive, but that from the very introduction of vaccination in 1800 they began to decrease, and have been getting less and less ever since. No other disease, it is said, has decreased in the same striking manner.
(2) This being the very foundation of the supposed evidence in favour of vaccination it is necessary to examine it closely, when it will be found to be wholly worthless, and to illustrate in a striking manner the complete ignorance of doctors, and also of the Royal [[p. 6]] Commissioners, of the very elements of statistical enquiry. This requires some little explanation, though it is really a very simple matter.
In order to be able to study the effect of any alleged cause of improved health of the community, we must compare the death-rates before and after the introduction of the supposed cause of improvement (in this case vaccination), and also compare these with the death-rates from other groups of diseases, and from all causes. These facts are given by the Registrar-General in tables showing the number of deaths each year in each million of the population. Now, small-pox, many fevers, cholera, etc. are what are termed epidemic diseases, which attack large populations at irregular intervals with great severity, while at other times they are far less fatal or more local. Hence the yearly death-rates vary enormously. In 1796 more than 4,000 per million died of small-pox in London, while in the next year there were only about 800, and the following year (1798) over 3,000. Again, in 1870 less than 100 per million died of it, while in 1871 there were about 300, and in 1872 about 2,500. Thus the figures go increasing and decreasing so suddenly and so irregularly, that by taking only a few years at one period, and a few at another, you can show an increase or a decrease according to what you wish to prove. Hence it is often ignorantly said that figures can be made to prove anything. But this is quite untrue. They can often be made to show anything, which is quite another matter; but if properly exhibited and compared they lead to one conclusion only; they show the truth.
[[p. 7]] (3) There are a few simple rules for getting at the truth in such statistics as we are now discussing. One is that we must take as long periods of time as possible; another is that we must use the largest populations available. Two other conditions are almost equally important; we must compare, when possible, equal periods before and after vaccination was introduced; and we must also compare the increase or diminution of small-pox with those of other diseases, in order to discover whether there is anything exceptional in the decrease of small-pox mortality which requires a peculiar cause to explain it.
But the ever-varying figures in long columns are so confusing to most people, that it is impossible to make anything out of them, and to simplify them, averages have to be taken, showing the deaths every five or every ten years, and in other ways, so as to find out what the figures really mean, and even then, by altering the periods or beginning at different years, a very different result may often be shown.
(4) By far the best way and that usually adopted by statisticians and mathematicians, is to draw out diagrams by which the whole course of the mortality from each disease or group of diseases can be seen and compared at a glance. From the various elaborate tables given in the Reports of the Royal Commission and from the annual reports of the Registrar-General, I constructed twelve diagrams, each showing the comparative rise or fall of small-pox mortality and other diseases in various places and under different conditions; and all these without exception demonstrate either that vaccination has no [[p. 8]] effect whatever, or that it tends to increase rather than decrease small-pox mortality. These are all given in my little book "Vaccination a Delusion," which can be had from the National Anti-Vaccination League for 9d. a copy, or 10½d. by post.
(5) As many people do not understand these diagrams
I here give a part of one of them in a simplified form in order to render
statistical diagrams intelligible to all, and it will serve to show
what is the nature of the evidence against vaccination, and also how
I prove that the statements made by the doctors and by the Royal Commissioners
are not only misleading but absolutely untrue. [[note:
diagram to follow originally filled p. 9]]
Explanation of the Diagram.
(6) The figures on the bottom and top of the diagram show the years, from 1770 to 1830, while those on the right and left show the number of deaths to each million of population. The three wavy lines show the proportion of deaths to population during this period of 60 years; the lower line the small-pox deaths; that next above it the deaths from the other zymotic diseases (fevers, diphtheria, whooping-cough, etc.); while the top line shows deaths from all diseases. These last deaths, being so much more numerous, have had to be drawn out on a smaller scale in order to show them on the same page as the others.
(7) This diagram shows us that small-pox decreased during the ten years before vaccination at very nearly the same rate as it did in the ten years after vaccination. The other zymotic diseases [[p. 10]] decreased even more than small-pox during the ten years after vaccination. General mortality also decreased after 1800 more rapidly than before 1800. Yet the Royal Commissioners declare that there was nothing but vaccination to produce the decrease of small-pox, and that there was no improvement in sanitation in the beginning of the nineteenth century, as compared with the latter part of the eighteenth century, to account for the difference.
(8) Now, in an Appendix to my "Vaccination a Delusion," I have given an account of a number of improvements affecting health at this very period which are amply sufficient to produce the results shown by the diagram, and I believe it is the most compact and most interesting account of these improvements yet given. The chief of them are (1) That many West-end squares and suburbs were built at this very period, and were inhabited chiefly by city people. (2) That the streets were more systematically cleaned and the roads improved. (3) That the water supply was much improved. (4) That potatoes, tea, and coffee came into more general use; while the better roads allowed more fresh meat, vegetables and milk to be used. (5) Cemeteries were formed outside London and many City graveyards were permanently closed. The result of these five groups of improvements was strikingly shown in the decrease of the death-rate in a number of the most fatal diseases (as recorded in a Table by Dr. Farr, reprinted in the Third Report of the Royal Commission) to fully one-half in 1801-10 as compared with 1771-80; an amount of [[p. 11]] improvement which has never occurred in any similar period during the whole of the 270 years for which we have official statistics. And yet the Royal Commissioners declare that nothing but vaccination can explain the corresponding and very similar decrease in small-pox!
(9) As you will now understand the method of exhibiting
statistics by means of diagrams, I will proceed to state the other more
important conclusions to be drawn from our national statistics of death-rates.
Those who wish to study them more fully must obtain the book itself,
and examine the diagrams and the full details there given.
[[p. 12]] III. London Death-Rates during Registration. 1838-96.
(1) These tables show us that neither the general mortality nor that from zymotic diseases decreased much till about 1868, but from that date there has been a large and continuous decrease. Small-pox had a sudden increase in 1838, in which year the mortality was greater than it had been for the preceding twenty-five years. Then it decreased slowly till 1870, and this decrease is always ascribed by the doctors to vaccination. But in 1871 there was a great epidemic, when the mortality was greater than at any period during the preceding seventy years of constantly increasing vaccination! Since 1871 small-pox has decreased, but only at about the same rate as the other zymotic diseases. The interesting thing to note here is, that the Main Drainage of London was completed in 1865, and about five years later (the time required for the connection of all the house drainage) the marked diminution in the mortality above-mentioned began to show itself. And if we average the enormous small-pox mortality of 1871 with that of the preceding ten years, we shall find that it will bring the small-pox mortality into almost exact correspondence with that from all other causes, and thus leave nothing to be imputed to vaccination!
(2) In another diagram in my book I show the mortality
from the five groups of zymotic diseases taken separately: Fevers, Whooping-cough,
Diphtheria and Scarlatina, Measles, and Small-pox, for [[p.
13]] the same period of Government Registration. All of these
diseases show a nearly similar decrease in the latter half of the period,
except measles, which shows hardly any diminution; but there is reason
to believe that the cause of this is, that, when vaccinated children
after a short illness die of small-pox, measles or chicken-pox are often
given as the cause of death.
[[p. 14]] IV. Death-Rates in England and Wales during the Period of Registration.
(1) My third diagram is one of the most instructive and conclusive in my book, because it deals with the whole population of England and Wales and the death-rates from various groups of diseases as in the illustrative diagram. In the first twenty-five years, from 1848 to 1872, there is on the average hardly any decrease either of general mortality, zymotics, or small-pox, since the enormous small-pox mortality of 1871-72 if distributed over the preceding ten years will bring it to correspond closely with the other classes of mortality. But from 1873 to 1895--the last twenty-three years shown--there is a diminution in all three of the diseases to a considerable amount. For the last ten years the diminution in small-pox is the greatest; but this can be proved to be not due to vaccination, as I will now explain.
(2) It is only from the year 1872 (after the great epidemic of small-pox) that all vaccinations, private as well as public, have been officially registered, and a table showing their amount has been given in the Final Report of the Royal Commission. From 1872 to 1882 the vaccinations amounted to 95 per cent. of the births; practically all were vaccinated if we allow for those that died before they could be operated on or very soon afterwards. But from that date the number of vaccinations steadily decreased, till in 1895 they were only 80 per cent. of the births, [[p. 15]] a diminution of 15 per cent. in fourteen years. If vaccination were the chief or only preventive of small-pox we ought to have a considerable increase of the disease during this period, instead of which it is in this period only that the diminution of small-pox has been more marked than that of the other zymotic diseases! Here, then, we have the first distinct proof that it is vaccination which keeps up the disease, and that when a larger number of children escape the blood-poisoning lancet small-pox diminishes!
Another and even more conclusive proof is given
on page 2 (back of the title-page) by Dr. Ruata, M.D.1
The whole male population of Italy are revaccinated on entering the
army. Under the age of 20, men and women are alike as regards
vaccination; afterwards men have an enormous advantage, if vaccination
is of any use. Yet, over 20, many more men than women die of
small-pox, while under 20 the mortality is equal, again demonstrating
that vaccination increases small-pox mortality!
[[p. 16]] V. Thirty Years of Rapidly Decreasing Vaccination in Leicester, and its Teachings.
(1) The great manufacturing town of Leicester, with nearly 200,000 inhabitants, affords the most conclusive proof of the uselessness of vaccination that it is possible to have; and the doctors and government officials carefully avoid dealing with it except to prophecy evils which have never come to pass.
Down to 1872 Leicester was one of the most completely vaccinated towns in the kingdom, the number of vaccinations, owing to alarm after epidemics, several times exceeding the number of births. Yet in 1871, at the very height of its good vaccination record, it was attacked by the epidemic with extreme severity, its small-pox deaths during that year being more than 3,500 per million of the population, or about a thousand per million more than the mortality in London during the same epidemic. If ever a test experiment existed it is this of Leicester, where an almost completely vaccinated community suffered more than unvaccinated and terribly insanitary London, on the average of the last forty years of the eighteenth century.
But even more conclusive evidence is to come.
(2) That fearful mortality destroyed the faith of Leicester in vaccination. Poor and rich alike, the workers and even the municipal authorities began to refuse vaccination for their children. This refusal continued till, in 1890, instead of 95 per cent. the vaccinations reached only 5 per cent. of the births! [[p. 17]] As this ominous decrease of vaccination went on the doctors again and again prophesied against it, that once small-pox was introduced it would run through the town like wildfire and decimate the population. Yet it has been introduced again and again, but it has never spread; and from that day to this no town in the kingdom of approximately equal population has had such a very low small-pox mortality as this almost completely unvaccinated and--as the doctors say--unprotected population! Surely this completes the demonstration that vaccination, instead of preventing, increases the liability to small-pox, and that the only way to abolish the disease is to do as Leicester did, leave off vaccination altogether and devote our energies to sanitation, and the isolation of such rare cases as do occur.
Yet this wonderfully conclusive test experiment
was passed over by the Royal Commissioners in 1894, with a few scattered
remarks, which are either absolutely untrue or entirely beside the question.
(See "Vaccination a Delusion," p. 277.)
[[p. 18]] VI. The Army and Navy: A Demonstration of the Uselessness of Vaccination.
(1) The doctors always claim that, though the effect of vaccination in infancy wears out, yet re-vaccination offers an almost complete protection for the rest of the person's life. In a circular issued in 1884, and up to the time of the Royal Commission widely distributed with the approval of the Local Government Board, it is stated that: "Soldiers who have been re-vaccinated can live in cities intensely affected by small-pox without themselves suffering to any appreciable degree from the disease." I will now show you that this official statement is absolutely false.
(2) All soldiers and sailors are re-vaccinated on entering the service, unless they have recently had small-pox. The reports of the Royal Commission give the small-pox deaths in the Army and Navy from 1860 to 1894. The Registrar-General gives the total mortality from disease in the two services for the same period. I have compared these two mortalities by means of a diagram constructed from the tables, and this is what we find. First, throughout the whole period the total mortality from all diseases in the Army is much higher than in the Navy. Clearly, this is the result of the one class living in barracks, largely in towns and cities, the other in the midst of the pure and bracing sea air.
In the second place, there has been, in both [[p. 19]] services, throughout the thirty-four years a continuous diminution of mortality, so that it is now only about one-third of what it was thirty-four years ago; and this enormous improvement is stated by the Army and Navy doctors to be due to the much better sanitation of ships and barracks, and to the great improvement in the food and general treatment and medical attention in both services.
Thirdly, in both Army and Navy there has been a large decrease in the small-pox mortality throughout the whole period, corresponding closely with that of the general mortality, and certainly due to the same causes--improved sanitation and medical treatment.
Fourthly, in the very same years (1871-2) as the great epidemic in England and on the Continent, there was also a small-pox epidemic both in the Army and the Navy, and taking account of the age of the men and their condition of constant medical supervision, quite as severe as among the general population, who had not the alleged complete protection of re-vaccination.
Fifthly, this is proved by two comparisons--with Ireland and with Leicester--from tables given in the Reports of the Royal Commission extending from 1864 to 1894. The diagrams formed from these tables show us that Irishmen of about the same ages as our soldiers and sailors suffered more during the epidemic of 1872, but for the remainder of the thirty years they had rather less small-pox mortality; while since 1881 they have had not half the small-pox mortality of the Army and Navy.
[[p. 20]] (3) The other comparison is with Leicester, which city, in the period of twenty years (1873-1892), during which they had been growing less and less vaccinated, has had a total of only 16 small-pox deaths per 100,000 of its population, which includes thousands of unvaccinated children and infants; while for the same period the deaths in the Army and Navy amounted to over 70 per 100,000.
And yet we have had the impudently false statement circulated by thousands, under the approval of the Local Government Board, that the re-vaccinated Army and Navy do not, under the worst circumstances, "appreciably suffer!" The Royal Commissioners, on the other hand, shirk the whole matter--make no comparisons with other populations--but state vaguely that "particular classes" who have been "exceptionally" re-vaccinated exhibit "quite exceptional advantages in relation to small-pox,"--a statement which, as regards the only "exceptionally" re-vaccinated large classes of men, is, as their own tables show, the very reverse of the truth, since they suffer much more than the least vaccinated class of about equal population in the whole kingdom.
It is thus absolutely demonstrated that it is the exceptionally unvaccinated that possess the exceptional advantages, while the "exceptionally re-vaccinated" Army and Navy show quite exceptional disadvantages, in a small-pox mortality during the same twenty years, more than four times as great as the exceptionally unvaccinated town of Leicester!
But the learned men of the Royal Commission never put these two facts side by side, so that the [[p. 21]] Government and the public might draw their own conclusions from them. So far as their Final Report shows, these gentlemen were ignorant or oblivious of the very existence of these facts, which conclusively prove that Vaccination is not only worthless but an injurious operation--a Gigantic Medical Imposture!
(4) For the reasons now stated, we call upon voters of all parties to refuse support to every candidate who upholds the legal or other enforcement of vaccination, which, as we have shown, both spreads disease and increases mortality. No government has the right to order healthy infants to be blood-poisoned, under the pretence of protection against a danger that may never arise. The abolition of all laws enforcing or encouraging vaccination is therefore of more immediate and vital importance than any party dogma or any political programme.
[Note.--The evidence against vaccination and the
misstatements of doctors and officials are fully and clearly set forth
in the author's pamphlet--"Vaccination a Delusion," to be obtained from
the National Anti-Vaccination League, price 10½d., post free.]
[[p. 22]] VII. How to Deal with Medical Pro-Vaccinators.
(1) In my "Vaccination a Delusion" I have given examples of the grossest misstatements of doctors and officials from the time of Jenner down to the present day. They are such as often appear to be incredible, but none of them have ever been disproved. Several have been given here; but there is one more which is so universal that it must be briefly referred to. In all Official Reports of small-pox epidemics the fatality of the unvaccinated is always declared to be enormous as compared with the vaccinated. As an example, Dr. Gayton, in a Table published in the Second Report of the Royal Commission, gives the percentage of deaths to cases as follows:--
Vaccinated--7.45 per cent.
But all the medical writers on small-pox during the eighteenth century agree in stating that the average death-rate of small-pox patients was then from fourteen to eighteen per cent. At that time, however, the sanitary state of our towns and hospitals was abominable, while the medical treatment of small-pox was so incredibly bad that it is a wonder any survived. Yet the doctors ask us to believe that now, with far healthier conditions and with far better treatment and nursing, more than twice as many unvaccinated small-pox patients die as died then, when all were unvaccinated! The thing is absolutely incredible and absurd; and the belief in it is due solely to the fact that doctors register all deaths from small-pox as "unvaccinated" when they can possibly find any excuse for doing [[p. 23]] so. One of them has stated that "the mere assertions of patients or their friends that they were vaccinated counts for nothing." The alleged enormous mortality of the unvaccinated is further shown to be erroneous by the fact that the published Reports of three of the largest small-pox hospitals for London from 1876 to 1879 showed that the average small-pox mortality of all patients was about 18 per cent., or a little higher than during the eighteenth century. This may be explained partly by the fact that many of the milder cases do not go to the hospitals, and partly by the weakening of the constitution due to the blood-poisoning operation of vaccination, which, when conditions are alike, renders the vaccinated less able to resist small-pox than the unvaccinated. It has been well asked: "If about 36 per cent. of unvaccinated patients die of small-pox while only about 18 per cent. died in the eighteenth century who or what kills the other 18 per cent.?" It cannot be the general conditions, since the mortality from all diseases has greatly diminished. There remains only the medical treatment. Do doctors accept this?
(2) Now if any one brings forward doctor's or official's figures as to the enormous value of vaccination, ask them first the above questions. They will deny the facts. Then, in my book you will find the official authority for these and all the other facts referred to. They will be obliged to say they have never enquired into them, and you may then tell them that they have no right to teach you who have enquired into them.
If you have a medical man to deal with, ask him why he does not admit Sir John Simon's statement, that "the great masses of national experience can alone prove the value of vaccination." Then [[p. 24]] show him the diagrams (in my book) which I have here referred to, and ask him to prove that they show "great benefits of vaccination," instead of showing as they do its absolute worthlessness.
(3) As to its terrible dangers, the thousands of lives vaccination has destroyed or ruined as regards health, I have no space to refer to them here, but ample evidence from the Royal Commission Reports is given in my book.
(4) Doctors and Members of Parliament are alike grossly ignorant of the true history of the effects of vaccination. They require to be taught; and nothing is so likely to teach them as to show them the diagrams I have referred to in this short exposition of the subject--those of London for thirty years before and after vaccination--of England and Wales during the period of official registration--of Leicester which has almost abolished small-pox by refusing to be vaccinated for thirty years--and for the Army and Navy--which, though thoroughly re-vaccinated and therefore (according to the doctors) as well protected as they possibly can be, yet die of small-pox at least as much as badly vaccinated Ireland, and many times more than unvaccinated Leicester.
A doctor who has not studied these most vital statistics has no right to an opinion on this subject.
A candidate for Parliament who will not give the necessary time and attention to study them, but is yet ready to vote for penal laws against those who know infinitely more of the question than he does, is utterly unworthy to receive a single vote from any self-respecting constituency.
1[communication from Dr. Ruata:] "There is another consideration which has a certain relation with vaccination and small-pox in the Italian Army. Our young men are obliged, by law, to enter the Army at the age of twenty, so that the greatest part of them pay this tribute to the State. The consequence is that, after the age of twenty years, men are by far better vaccinated than women, and after the age of twenty small-pox should kill less men than women. I wished to ascertain if this were true, and here are the figures representing the numbers of deaths from small-pox in men and in women before and after the age of twenty during our great epidemical years, 1887-88-89:--
Under Twenty . . . . . . . . . 5,997 / 5,983
7,349 / 7,353 5,626
/ 5,631 18,972 / 18,968
"All the following years until the last-known (1897) give the same results.
"I had care to send you these facts, which every one can appreciate as he thinks best; and I hope that, for love of truth, you will publish them in the British Medical Journal."
I remain, dear Sir,
Yours most faithfully,
Charles Ruata, M.D.,
of Materia Medica in the University of Perugia,
* * * * *
During the decades surrounding the start of the Twentieth Century, Victorian society was jolted by a civil movement against the smallpox vaccination program imposed by the English Government. A preconceived fear of the artificial inoculation of the virus in the human body produced a reaction from both the common people and the clergy--and even from progressive politicians, one of whose main agenda was a general reform of public health policies. Wallace took an active role in the campaign, and in the present work (as well as in the main ones that preceded it: S374 and S536) pointed out that although the second half of the Nineteenth Century had witnessed a decrease in the number of smallpox-caused deaths, the number of epidemics had actually grown steadily. He claimed that while it was possible to show that vaccination had effectively increased the number of epidemics, there was no evidence that it had led to a decrease in the death rate. Wallace denied, for example, the 1883 official figures regarding the situation at the Metropolitan Hospital: according to these statistics smallpox had killed 45% of the unvaccinated victims, and only 15% of the vaccinated. Wallace pointed out that the aged, weak children, tramps, and criminals who had escaped the program were included among the unvaccinated; thus this category included the weakest and most ill individuals to begin with. Wallace also noted that many people, driven by fear, had exhibited false documents claiming they were already vaccinated.
Wallace's moral principles and liberal and socialist beliefs played an important role in leading him to view mandatory vaccination as an unbearable imposition on personal freedom and privacy. Meanwhile, his vision of harmonia naturae (the world viewed as the tangible manifestation of an unbroken and harmonious system) induced him to hypothesize a certain compatibility and co-existence between man and microbe. On the one hand, and in accordance with the law of survival of the fittest, germs/viruses have a role in eliminating the weakest organisms (a notion similar to ideas held at that time on the nature of human warfare). But in human society, Wallace maintained, solidarity and civil progress are more important. Healthy living conditions can be achieved by proper hygiene and a good diet. A man who is physically and mentally healthy is potentially unassailable by diseases. The use of chemicals in medicine could thus disrupt the delicate natural balance, and have a negative rather than beneficial effect.
Today it is easy to smile at those who in the decades around 1900 fought to abolish vaccination. But there was more to this reform-minded civil protest than mere superstition, factiousness or obscurantism. Claiming that vaccination was responsible for killing lives rather than saving them was certainly hyperbole; nevertheless, it is sometimes true that medical innovations can, if applied with excessive vigor, prove harmful. Here, it should not be forgotten that the process of inactivation of the vaccinal lymph was yet to be invented. Later on, smallpox was eradicated--by using the same tool (i.e. vaccination), but through vaccine doses that were much reduced and purified compared to those used during Wallace's time, which are today known to cause serious side effects.