Sequence-specific DNA detection using engineered DNA-binding proteins

The sensitive detection of DNA is of great interest and demand for an increasing number of biomedical studies and diagnostic applications. The development of simple, rapid, and robust technologies for detection of pathogens is becoming particularly critical, considering the increasing rate of mortality and risk of bacteremia. The use of DNA-binding proteins provides a useful scaffold for ‘direct’ reading of the sequence...

Identification of novel bioactive compounds from sunflower family (Compositae) and their target proteins for prevention of common disease

Some secondary metabolites from natural plants exhibit biological activities. Among them, sesquiterpene lactones have been shown to possess a wide variety of biological properties such as anti-tumoral, anti-inflammatory, and anti-microbial activities. We are interested in identifying novel sesquiterpene lactones from natural product. We systematically investigate the effect of sesquiterpene lactones on the expression of...

Current Research Support


• NSF
Kentucky Biomedical Research Infrastructure Network (KBRIN)-NIH INBRE
• KY NSF EPSCoR-REG
• WKU- ARTP Collaborative Research Proposal