Kevin M. Williams, Ph.D.

Associate Professor, Department of Chemistry

Education

• Emory University, Department of Chemistry. Atlanta, GA. 1994-2000
• Ph.D., Chemistry. Luigi G. Marzilli, advisor
• Dissertation title: Effects of Carrier Ligands on Platinum Anticancer Drug Chemistry
• The University of Virginia's College at Wise. Wise, VA. 1990-1994
• B.S., Chemistry/Mathematics, summa cum laude

Professional Experience

• Western Kentucky University, Department of Chemistry. Bowling Green, KY.
• Associate Professor, 2008
• Assistant Professor, 2002
• Vanderbilt University School of Medicine, Department of Biochemistry. Nashville, TN.
• Postdoctoral fellow, 2000-2002
• Eastman Kodak Company, Organic Chemicals Division. Kingsport, TN.
• Summer Intern, 1992

Courses Taught

• Fundamentals of Organic Chemistry (CHEM 107)
• Survey of organic chemistry and biochemistry for agriculture and non-science majors
• Introduction to College Chemistry (CHEM 116)
• One semester course designed to prepare students for College Chemistry (for science majors)
• Honors College Chemistry Laboratory (CHEM 121H)
• Laboratory section to accompany College Chemistry I, with unique experiments themed around "metals in biology"
• Principles of Inorganic Chemistry (CHEM 320)
• Introduces descriptive inorganic chemistry principles at a level not requiring physical chemistry and calculus
• Biochemistry I (CHEM/BIOL 446(G))
• Discusses structure/function relationships of proteins, nucleic acids, lipids and carbohydrates as well as three metabolic pathways
• Biochemistry Laboratory (CHEM/BIOL 447(G))
• Laboratory utilizing techniques including SDS-PAGE, western blotting, Michaelis-Menten kinetic assays, chromatographic separations
• Biochemistry II (CHEM/BIOL 467(G))
• Discusses reactions and regulation of several major metabolic pathways
• Bioinorganic Chemistry (CHEM 462 (G))
• Covers metal ion toxicity, metals in medicine, ion transport and storage, and metalloenzyme mechanisms
• Toxicology (special topics course, independent study) (CHEM 475G)
• Introduction to environmental and molecular toxicology
• Chemical Skills (CHEM 580)
• Introduction to library research for graduate students
• Ethics in Scientific Research (HON 300)
• Honors colloquium discussing key issues related to ethics in scientific and medical research
• Fuels of the Future (HON 300)
• Honors colloquium in which students choose a number of purported alternative fuels and evaluate them for overall viability

Research Activities

• Western Kentucky University, Department of Chemistry. 2002-Present
• Studying DNA and protein complexes with platinum anticancer drug analogs by NMR spectroscopy, molecular modeling, ICP-AES, gel electrophoresis, mass spectrometry
• Funded by WKU Junior Faculty Fellowship, KY NSF EPSCoR, Materials Characterization Center Faculty Enhancement Grant, Research Corporation Cottrell College Grant, NIH AREA grant
• Studying interaction of ruthenium(II) and ruthenium(III) complexes with proteins and amino acids by NMR spectroscopy, UV/Vis spectroscopy, and other techniques
• Funded by KY NSF EPSCoR
• Utilizing dielectric and impedance methods to study biologically relevant systems
• Collaboration with Dr. Alan Riga, Dr. Wei-Ping Pan, Dr. Stuart Burris
• Vanderbilt University School of Medicine, Department of Biochemistry. 2000-2002
• Studied ethylene dibromide adducts with alkylguanine transferase by mass spectrometry
• Collaboration with Liping Liu and Dr. Tony Pegg (Penn State University School of Medicine)
• Studied reaction of aflatoxin B₁ with lysine by mass spectrometry
• Collaboration with Dr. Tom Harris (Chemistry)
• Emory University, Department of Chemistry. 1995-2000

• Studied complexes of guanine derivatives with platinum anticancer drug analogs by NMR spectroscopy, CD spectroscopy, molecular modeling
• Collaboration with Dr. Giovanni Natile (Università di Bari), Dr. Renzo Cini (Università di Siena)

Selected Service Activities

• Chemistry Advisor, 2003-present
• Typically advise 40-50 students per semester
• Department Committees and Service
• Biochemistry Search Committee Chair, 2008-2009
• Inorganic Search Committee, 2007
• Organic Search Committee, 2005-2006
• Tenure and Promotion, 2003-2004
• Education, 2003-present
• Chair, 2006-present
• Department Webmaster, 2003-2004
• Chemistry Club (ACS Student Affiliate Chapter) Advisor, 2004-2006
• Chapter won Honorable Mention award from ACS, 2004-2005
• Chapter won Commendable award from ACS, 2005-2006
• College Committees
• Ogden College Student Awards Committee, Spring 2004, 2005, 2006
• Ogden College Curriculum Committee, Spring 2008
• University Committees and Service
• Alternate, University Senate, 2005-2006
• Alternate, Professional Education Council, 2006-2007
• Honors Development Board, 2006-2009
• Search Committee, Assistant Director of Academics, Honors College, 2008
• Barry M. Goldwater Scholarship Faculty Representative, 2006-present
• Two scholars, one honorable mention in 2006-2007
• Two scholars, two honorable mentions in 2007-2008
• One scholar, two honorable mentions in 2008-2009
• University Presentations
• Student Attendance at National Meetings co-presenter, 2006
• Balancing Teaching and Research panelist, 2007
• Student Engagement panelist, 2007
• Prestigious Scholarships co-presenter, 2007
• Technology for Instruction panelist, 2008
• Public Service
• Southern Kentucky Regional Science Fair judge, 2004
• Kentucky Science Olympiad event supervisor, 2005, 2006, 2007
• Student Research Conference judge, 2005
• Chemistry judge, Kentucky Academy of Science annual meeting, 2004

Honors and Awards

• Nominee, University Faculty Award for Research/Creativity, Spring 2007
• University of Virginia's College at Wise Outstanding Young Alumni Award, Fall 2001
• ARCS Foundation fellowship, Fall 1997-Spring 1999
• Joseph C. Smiddy Science Award (UVa-Wise), Spring 1994
• Mathematics department award (UVa-Wise), Spring 1994
• Northeast Tennessee Section ACS Outstanding Chemistry Major, Spring 1994
• Barry Goldwater Scholar, Fall 1993-Spring 1994
• Chemical Rubber Company freshman chemistry award, Spring 1991

Professional Societies

• American Chemical Society, member. 1995-Present
• Division of Inorganic Chemistry, member
• Division of Chemical Toxicology, member
• Kentucky Academy of Sciences, member. 2002-Present

Funding

External

• Williams, K.M. "Reaction of bulky platinum complexes with proteins", NIH R15 (AREA), 1/8/2007-12/31/2010. $197,450.
• Williams, K.M. "Ruthenium Complexes as Protein Cleavage Agents", Kentucky NSF EPSCoR, 5/1/2005-4/30/2007. $22,824.
• Williams, K.M. "Cleavage of Proteins by Bulky Platinum Complexes", Research Corporation Cottrell College Grant, 5/15/2005-5/14/2009. $29,576.
• Holman, R.H.; Williams, K.M.; Pesterfield, L.; Shon, Y.-S.; Salvatore, R. "Acquisition of Nuclear Magnetic Resonance Spectrometer", NSF Major Research Instrumentation (MRI), 7/1/2003-6/30/2006. $349,200.
• Williams, K.M. "Experimental and Computational Studies of the Competition between Guanine and Methionine Complex Formation by Analogs of the Anticancer Drug Cisplatin", Kentucky NSF EPSCoR, 3/1/2003-12/31/2004. $25,000.

Internal

• Williams, K.M. "Reaction of halogenated hydrocarbons with cysteine and DNA", WKU Summer Faculty Scholarship, 5/15/2010-5/14/2011, $6,000.
• Williams, K.M. "Untitled", Materials Characterization Center, 10/1/2006-5/15/2007, $4,000.
• Williams, K.M. "Interaction of platinum complexes with peptides and proteins", Materials Characterization Center Student Research Grant Program, 1/1/2006-6/31/2006, $4,000.
• Williams, K.M. "Cleavage of proteins by bulky platinum complexes", Summer Faculty Scholarship, 5/15/2005-5/14/2006, $5,000.
• Williams, K.M. "Cleavage of Cytochrome c by Platinum Diamine Complexes", Materials Characterization Center Faculty Grant, 1/1/2005-6/30/2005, $5,000.
• Williams, K.M. "Determination of the Binding of Cisplatin Analogs to Proteins", Materials Characterization Center Faculty Grant, 2/2/2004-12/31/2004. $5,000.
• Williams, K.M. "DNA and Protein Complexes of Cisplatin", Western Kentucky University Junior Faculty Fellowship, 3/13/2003-3/13/2004. $4,000.

Peer-Reviewed Publications (Click on title for abstract)

WKU

• Sandlin, R.D.; Starling, M.P.; Williams, K.M. "A bulky platinum triamine complex that reacts faster with guanosine 5'-monophosphate than with N-acetylmethionine", J. Inorg. Biochem., 2010, 104, 214-216.
• Riga, A.T.; Alexander, K.S.; Williams, K. "Thermal and Oxidative Properties of Physiologically Relevant Free Fatty Acids by Dielectric Analysis and Differential Scanning Calorimetry", J. ASTM Int., 2007, 4 (3).
• Williams, K.M.; Chapman, D.J.; Massey, S.R.; Haare, C. "Interaction of N-acetylmethionine with a non-C₂-symmetrical platinum diamine complex", J. Inorg. Biochem., 2005, 99, 2119-2126.
• Williams, K.M.; Rowan, C.; Mitchell, J. "Effect of Amine Ligand Bulk on the Interaction of Methionine with Platinum(II) Diamine Complexes", Inorg. Chem., 2004, 43, 1190-1196.

Vanderbilt

• Liu, L.; Wantanabe, K.; Fang, Q.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E. "Effect of Alterations of Key Active Site Residues in O⁶-Alkylguanine-DNA-Alkyltransferase on its Ability to Modulate the Toxicity of 1,2-Dibromoethane"; Chem. Res. Toxicol., 2007, 20, 155-163.
• Liu, L.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E. "O6-Alkylguanine-DNA Alkyltransferase has Opposing Effects in Modulating the Genotoxicity of Dibromomethane and Bromomethyl Acetate", Chem. Res. Toxicol., 2004,17, 742-752.

• Liu, L.; Hachey, D.L.; Valadez, G.; Williams, K.M.; Guengerich, F.P.; Loktionova, N.A.; Kanugula, S.; Pegg, A.E. "Characterization of a Mutagenic DNA Adduct formed from 1,2-Dibromoethane by O⁶-Alkylguanine-DNA Alkyltransferase", J. Biol. Chem., 2004, 279, 4250-4259.
• Guengerich, F.P.; Williams, K.M.; Sutter, T.R.; Hayes, J.D.; Johnson, W.W.; Arneson, K.O.; Voehler, M.; Deng, Z.W.; Harris, T.M. "Competing Reactions of Aflatoxin B₁ Dialdehyde: Enzymatic Reduction vs. Adduction with Lysine", ACS Sym. Ser., 2004, 865, 171-182.
• Liu, L.; Pegg, A.E.; Williams, K.M.; Guengerich, F.P. "Paradoxical Enhancement of the Toxicity of 1,2-dibromoethane by O⁶-Alkylguanine-DNA Alkyltransferase", J. Biol. Chem., 2002, 277, 37920-37928.
• Guengerich, F.P.; Voehler, M.; Williams, K.M.; Deng, Z.; Harris, T.M. "Structure of the Aflatoxin B₁ Dialdehyde Adduct Formed from Reaction with Methylamine", Chem. Res. Toxicol., 2002, 15, 793-798.
• Guengerich, F.P.; Arneson, K.O.; Williams, K.M.; Deng, Z.; Harris, T.M. "Reaction of Aflatoxin B₁ Oxidation Products with Lysine", Chem. Res. Toxicol., 2002, 15, 780-792.
• Nakamura, K.; Hanna, I.H.; Cai, H.; Nishimura, Y.; Williams, K.M.; Guengerich, F.P. "Coumarin Substrates for Cytochrome P450 2D6 Fluorescence Assays", Anal. Biochem., 2001, 292, 280-286.

Emory

• Williams, K.M.; Scarcia, T.; Natile, G.; Marzilli, L.G. "Imprinting Structural Information from a GpG Ligand into the Configuration of a Chiral Diamine Ligand through Second-Sphere Communication in Platinum(II) Complexes" Inorg. Chem., 2001, 40, 445-454.
• Williams, K.M.; Cerasino, L.; Natile, G.; Marzilli, L.G. "cis-Pt(NH₃)₂(GpG) Properties Interpreted through Comparison with Retro-Model GpG Adducts Having Carrier Ligands Designed to Slow Dynamic Motion". J. Am. Chem. Soc., 2000, 122, 8021-8030.
• Sunderam, V.; Cheung, S.Y.; Chodrow, S.; Gray, P.; Grigni, M.; Hirsch, M.; Hutto, P.; Krantz, A.; Olesen, S.; Rhee, I.; Goddard, T.; Sult, J.; Migliardi, M.; Marzilli, L.; Ano, S.; Williams, K.; Sullivan, S. "CCF: A Framework for Collaborative Computing". IEEE Internet Comput., 2000, 4, 16-24.
• Williams, K.M.; Cerasino, L.; Intini, F.P.; Natile, G.; Marzilli, L.G. "Effects of Six-Membered Ring Conformation on the Rotamer Distribution and Rate of Atropisomerization in Platinum(II)-Guanine Compounds: 2,4-Bis(methylamino)pentane Complexes". Inorg. Chem., 1998, 37, 5260-5268.
• Cerasino, L.; Williams, K.M.; Intini, F.P.; Cini, R.; Marzilli, L.G.; Natile, G. "Factors Influencing the Configuration and Conformation of Diamine Chelate Rings in Platinum(II) Compounds: 2,4-Bis(methylamino)pentane Complexes". Inorg. Chem., 1997, 36, 6070-6079.

Presentations and Abstracts (Presenter underlined; click on title for abstract, if available)

WKU

• Starling, M.P.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 237^th Annual American Chemical Society Meeting; 2009.
• Lively, R.; Williams, K.M. "Characterization of products between cisplatin analogs and selenomethionine". 237^th Annual American Chemical Society Meeting; 2009.
• Starling, M.P.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 29^th Annual Student Research Conference (University of Memphis); 2009.
• Starling, M.P.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 39^th Annual Student Research Conference (WKU); 2009.
• Sahi, N.; Williams K.M. " Reaction of Methionine with a Non-C2-Symmetrical Platinum(II) Diamine Compound". Kentucky Honors Roundtable; 2009.
• Turner, E.M.; Williams, K.M. "Modeling Thiolate Enzyme Chemistry with Cysteine at High pH". 60^th Southeastern Regional Meeting of the American Chemical Society; 2008.
• Starling, M.P.; Sandlin, B.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 60^th Southeastern Regional Meeting of the American Chemical Society; 2008.
• Lively, R.; Chmley, S.C.; Williams, K.M. " Reaction of Cisplatin Analogs with Selenomethionine". 60^th Southeastern Regional Meeting of the American Chemical Society; 2008.
• Sahi, N.; Williams, K.M. " Reaction of Methionine with a Non-C2-Symmetrical Platinum(II) Diamine Compound". 60^th Southeastern Regional Meeting of the American Chemical Society; 2008.
• Starling, M.P.; Sandlin, B.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 94^th annual Kentucky Academy of Science Meeting; 2008.
• Liao, Y.Y.; Williams, K.M. "Reaction of methionine derivatives with a platinum(II) diamine compound". 94^th annual Kentucky Academy of Science Meeting; 2008.
• Sahi, N.; Williams, K.M. " Reaction of Methionine with a Non-C2-Symmetrical Platinum(II) Diamine Compound". 94^th annual Kentucky Academy of Science Meeting; 2008.
• Williams, K.M. "Effects of Size and Shape of Cisplatin Analogs on the Reactions with DNA and Protein Targets". Invited seminar, University of Memphis Department of Chemistry; 2008
• Williams, K.M. "Using controversies to promote critical thinking in the sciences". Kentucky Conference on the Scholarship of Teaching and Learning, Lexington, KY; 2008.
• Lively, R.; Chmley, S.C.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 38^th annual student research conference, Bowling Green, KY; 2008.
• Lively, R.; Chmley, S.C.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 235^th Annual American Chemical Society Meeting, New Orleans, LA; 2008.
• Williams, K.M. "Use of a wiki to enhance group projects". 235^th Annual American Chemical Society Meeting, New Orleans, LA; 2008.
• Lively, R.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 93^rd Annual Kentucky Academy of Science Meeting, Louisville, KY; 2007.
• Lively, R.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 37^th annual student research conference, Bowling Green, KY; 2007.
• Sandlin, B.M.; Williams, K.M. "Factors affecting the rate of reaction of platinum anticancer drug models with DNA and protein targets". 37^th annual student research conference, Bowling Green, KY; 2007. [won 1^st place in oral presentations within chemistry and geography/geology section]
• Gibson, S.C.; Williams, K.M. "Reduction of ruthenium(III) complexes to promote reaction with proteins". 233^rd Annual American Chemical Society Meeting, Chicago, IL; 2007.
• Sandlin, B.M.; Williams, K.M. "Factors affecting the rate of reaction of platinum(II) complexes with DNA and protein targets". 233^rd Annual American Chemical Society Meeting, Chicago, IL; 2007.

• Gibson, S.C.; Williams, K.M. "Reduction of ruthenium(III) complexes to promote reaction with proteins". 92^nd Annual Kentucky Academy of Science Meeting, Morehead, KY; 2006.
• Sandlin, B.M.; Williams, K.M. "Factors affecting the rate of reaction of platinum(II) complexes with DNA and protein targets". 92^nd Annual Kentucky Academy of Science Meeting, Morehead, KY; 2006. [won 2^nd place in oral presentations within chemistry section]
• Davis, B.M.; Williams, K.M. "Effects of amine ligand bulk on the rate of reaction of platinum(II) diamine complexes with guanine and methionine residues." 36^th annual student research conference, Bowling Green, KY; 2006. [won 2^nd place in oral presentations in chemistry and engineering section]
• Chapman, D.J.; Williams, K.M. "NMR studies of the reaction of platinum complexes with a peptide." 36^th annual student research conference, Bowling Green, KY; 2006.
• Chmely, S.C.; Williams, K.M. "Reaction of Selenomethionine with Platinum Complexes." 36^th annual student research conference, Bowling Green, KY; 2006. [won 3^rd place in oral presentations in chemistry and engineering section]
• Davis, B.M.; Williams, K.M. "Effects of amine ligand bulk on the rate of reaction of platinum(II) diamine complexes with guanine and methionine residues." 231^st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
• Bragg, S.A.; Hobbs, A.M.; Pesterfield, L.L; Williams, K.M. "Combining chemistry activities with service opportunities in a Student Affiliate chapter." 231^st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
• Chapman, D.J.; Williams, K.M. "Molecular Mechanics Predictions, Verifications, and Trends for N-acetylmethionine Reactions with Bulky Platinum Compounds." 231^st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
• Chmely, S.C.; Williams, K.M. "Reaction of Selenomethionine with Platinum Complexes." 231^st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
• Alicie, B.; Moore, A.; Williams, K.M. "Reaction of ruthenium(III) complexes with heterocyclic ligands and glutathione." 231^st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
• Davis, B. M.; Williams, K.M. "Effects of amine ligand bulk on the rate of reaction of platinum(II) diamine complexes with guanine and methionine residues." 91^st Annual Kentucky Academy of Science Meeting, Richmond, KY; 2005.
• Alicie, B.; Moore, A.; Williams, K.M. "Reaction of Ruthenium(III) Complexes with Heterocyclic Ligands and Glutathione". 91^st Annual Kentucky Academy of Science Meeting, Richmond, KY; 2005.
• Chmely, S.C.; Williams, K.M. "Interaction of platinum complexes with selenomethionine". 57^th Annual Southeast Regional Meeting of the American Chemical Society, Memphis, TN; 2005.
• Williams, K.M. "Platinum in Biochemistry: From Cancer Drugs to Protein Cleavage", Departmental Seminar, Western Kentucky University, 2005.
• Davis, B.; Bradley, M.S.; Lam, A.P.; Williams, K.M. "Effects of amine ligand bulk in platinum diamine complexes on the rate of reaction with DNA and protein residues". 35^th annual student research conference, Bowling Green, KY; 2005. [won 2^nd place in overall poster presentations]
• Massey, S.R.; Williams, K.M. "Reaction of N-acetylmethionine with a non-C₂-symmetrical platinum diamine complex". 35^th annual student research conference, Bowling Green, KY; 2005.
• Davis, B.; Bradley, M.S.; Lam, A.P.; Williams, K.M. "Effects of amine ligand bulk in platinum diamine complexes on the rate of reaction with DNA and protein residues". 229^th Annual American Chemical Society Meeting, San Diego, CA, 2005.
• Milner, K.; Hobbs, A.M.; Culver, J.P.; Williams, K.M. "Western Kentucky University Student Affiliate Chapter". 229^th Annual American Chemical Society Meeting, San Diego, CA, 2005.
• Massey, S.R.; Williams, K.M. "Reaction of N-acetylmethionine with a non-C₂-symmetrical platinum diamine complex". 229^th Annual American Chemical Society Meeting, San Diego, CA, 2005.
• Chapman, D.J.; Williams, K.M. "Molecular mechanics analysis of platinum complexes with methionine residues". 229^th Annual American Chemical Society Meeting, San Diego, CA, 2005.
• Chapman, D.J.; Rowan, C.; Williams, K.M. "Molecular mechanics analysis of bulky platinum complexes with DNA and protein residues". 56^th Annual Southeast Regional Meeting of the American Chemical Society, Raleigh, NC, 2004.
• Massey, S.R.; Williams, K.M. "Reaction of methionine with bulky platinum diamine complexes". 56^th Annual Southeast Regional Meeting of the American Chemical Society, Raleigh, NC, 2004.
• Davis, B.; Bradley, M.S.; Lam, A.P.; Williams, K.M. "Effects of Amine Ligand Bulk on the Rate of Reaction with DNA and Protein Residues by Platinum Complexes". 90^th Annual Kentucky Academy of Science Meeting, Murray, KY, 2004.
• Chapman, D.J.; Rowan, C.; Williams, K.M. "Molecular mechanics analysis of bulky platinum complexes with DNA and protein residues". 90^th Annual Kentucky Academy of Science Meeting, Murray, KY, 2004.
• Massey, S.R.; Rowan, C.; Williams, K.M. "Reaction of methionine with bulky platinum diamine complexes". 90^th Annual Kentucky Academy of Science Meeting, Murray, KY, 2004. [won 3^rd place award in chemistry oral presentations]
• Whitely, N.R.; Riga, A.T.; Clauson, M.; Williams, K.M.; Pan, W.-P. "Qualitative Detection of Biological Species Using Electrochemical Methods". The 32nd Annual Conference on Thermal Analysis and Applications, Williamsburg, VA 2004.
• Pan, W.-P.; Riga, A.T.; Williams, K.; Whitely, N. "Calorimetric and Dielectric Properties of Physiologically Relevant Fatty Acids". The 13^th International Congress on Thermal Analysis and Calorimetry, Sardinia, Italy, 2004.
• Gollapudi, K.; Williams, K.M. "Determination of the Binding of Cisplatin Analogs to Proteins". 10^th Annual Kentucky EPSCoR Conference, Lexington, KY; 2004.
• Whitely, N.; Clauson, M.; Williams, K.; Pan, W.-P. "Novel Detection of Biological Species using Dielectric Analysis". 34^th annual student research conference, Bowling Green, KY; 2004.
• Gollapudi, K.; Williams, K.M. "Determination of the Binding of Cisplatin Analogs to Proteins". 34^th annual student research conference, Bowling Green, KY; 2004.
• Bradley, M.S.; Williams, K.M. "Effects of Amine Ligand Bulk on the Rate of Reaction with DNA and Protein Residues by Platinum Complexes". 34^th annual student research conference, Bowling Green, KY; 2004.
• Gollapudi, K.; Rowan, C.; Williams, K.M. "Model DNA and Protein Adducts formed with a Bulky Platinum Diamine Complex". 89^th Annual Kentucky Academy of Sciences Meeting, Bowling Green, KY; 2003.
• Bradley, M.S.; Williams, K.M. "Effects of Amine Ligand Bulk on the Rate of Reaction with DNA and Protein Residues by Platinum Complexes". 89^th Annual Kentucky Academy of Sciences Meeting, Bowling Green, KY; 2003.
• Williams, K.M. "Analogs of the Anticancer Drug Cisplatin and their Interactions with DNA and Protein Targets". Departmental Seminar, Western Kentucky University, 2003.
• Williams, K.M. "Computational and Experimental Studies of the Interaction of Cisplatin Analogs with Methionine". Invited Seminar, Murray State University Department of Chemistry; 2003.
• Williams, K.M.; Rowan, C.; Mitchell, J. "Experimental and Computational Studies of the Competition between DNA and Protein Complex Formation by Platinum Anticancer Compounds". 9^th Annual Kentucky EPSCoR Conference, Lexington, KY; 2003.

Vanderbilt

• Williams, K.M.; Liu, L.; Pegg, A.E.; Guengerich, F.P. "Enhancement of Toxic and Mutagenic Effects of Ethylene Dibromide by Alkylguanine-DNA Alkyltransferase". The 224^th Annual American Chemical Society Meeting, Boston, MA; 2002.
• Guengerich, F.P.; Voehler, M.; Williams, K.M.; Arneson, K.O.; Deng, Z.; Harris, T.M. "A protein adduct formed from the reaction of a dialdehyde derivative of aflatoxin B1 with BSA". The 224^th Annual American Chemical Society Meeting, Boston, MA; 2002.
• Guengerich, F.P.; Voehler, M.; Williams, K.M.; Arneson, K.O.; Deng, Z.; Harris, T.M. "Reaction of Aflatoxin B1 Oxidation Products with Lysine". The 224^th Annual American Chemical Society Meeting, Boston, MA; 2002.
• Williams, K.M.; Liu, L.; Pegg, A.E.; Guengerich, F.P. "Mass Spectrometry Studies of Oligonucleotides Cross-Linked to Alkylguanine Transferase via Ethylene Dibromide". The 41^st Annual Society of Toxicology Meeting, Nashville, TN; 2002, 1716.
• Guengerich, F.P.; Arneson, K.O.; Williams, K.M.; Deng, Z.; Harris, T.M. "Reaction of Aflatoxin B1 Oxidation Products with Lysine and Proteins". 93^rd Annual American Association for Cancer Research Meeting, San Francisco, CA; 2002.

Emory

• Marzilli, L.G.; Williams, K.; Sullivan, S.; Marzilli, P.; Saad, J.; Kuklenyik, Z.; Ano, S.; Fannizi, F.; Natile, G. "Retro-modeling in Pt anticancer drug chemistry aided by MM methods". The 219^th Annual American Chemical Society Meeting, San Francisco, CA; 2000.
• Marzilli, L.G.; Williams, K.; Sullivan, S.; Villanueva, J.; Ano, S. O.; Marzilli, P.; Saad, J.; Ciccarese, A.; Intini, F.; Fannizi, F.; Natile, G. "Retro-modeling in Pt anticancer drug chemistry". The 9^th International Conference on Biological Inorganic Chemistry (ICBIC), Minneapolis, MN; 1999.