Kevin M. Williams, Ph.D.
Professor
Department of Chemistry
Western Kentucky University
Phone: 270-745-8899
e-mail: kevin.williams@wku.edu
Education
January 2000 Ph.D., Chemistry, Emory University
Advisor: Luigi G. Marzilli, Ph.D.
Effects of Carrier Ligands on Platinum Anticancer Drug Chemistry
May 1994 B.S., Chemistry/Math, The University of Virginia's College at Wise
Summa cum laude
Professional Experience
2002-Present Department of Chemistry, Western Kentucky University
· Professor, 2014
· Associate Professor, 2008
· Assistant Professor, 2002
2000-2002 Department of Biochemistry and Center in Molecular Toxicology,
Vanderbilt University School of Medicine
· Postdoctoral fellow, 2000-2002
Summer 1992 Eastman Kodak Company, Organic Chemicals Division.
· Summer Tech Intern
Honors and Awards
2015 Office of Sponsored Programs Prolific Proposer
2013 Ogden College Faculty Award for Advising
2001 University of Virginia's College at Wise Outstanding Young Alumni
1997-1999 ARCS Foundation fellowship
1993 Barry Goldwater Scholarship
Professional Societies
1995-Present American Chemical Society
2002-Present Kentucky Academy of Sciences
Courses Taught
CHEM 107 Fundamentals of Organic Chemistry
CHEM 116 Introduction to College Chemistry
CHEM 121(H) Honors College Chemistry Laboratory
CHEM 314 Introduction to Organic Chemistry
CHEM 320 Principles of Inorganic Chemistry
CHEM 446 (446G) Biochemistry I
CHEM 447 (447G) Biochemistry Laboratory
CHEM 467 (467G) Biochemistry II
CHEM 462 (462G) Bioinorganic Chemistry
CHEM 475G Toxicology (special topics)
CHEM 535 Bioanalytical Chemistry
HON 300 Ethics in Scientific Research
HON 300 Fuels of the Future
Research Activities
2002-Present Western Kentucky University, Department of Chemistry
§ Studying DNA and protein complexes with platinum anticancer drug analogs by NMR spectroscopy, molecular modeling, ICP-ES, gel electrophoresis, mass spectrometry, HPLC
§ Investigating effects of structure of platinum diamine complex on cytotoxicity and uptake (collaboration with Dr. Blairanne Williams)
§ Investigating platinum triamine complex cytotoxicity and ototoxicity in zebrafish models (collaboration with Dr. Michael Smith)
§ Investigating methods to stabilize polyunsaturated fatty acids in foods (collaboration with Dr. John Khouryieh)
2000-2002Vanderbilt University School of Medicine, Department of Biochemistry.
§ Studied ethylene dibromide adducts with alkylguanine transferase by mass spectrometry
§ Studied reaction of aflatoxin B1 with lysine by mass spectrometry
1995-2000Emory University, Department of Chemistry.
§ Studied complexes of guanine derivatives with platinum anticancer drug analogs by NMR spectroscopy, CD spectroscopy, molecular modeling
Selected Service Activities
Statewide
2017-Present Steering Committee, Kentucky Biomedical Research Infrastructure Network
Public
2010-2016 Reviewer/content generator, Berg, Tymoczko, Stryer's Biochemistry
2012 Reviewer, Miesfeld and McEvoy's Biochemistry
2009 Panelist, NSF MRI program
University
2015-Present Faculty Representative, Research and Creative Activities Council
2015 Chair, Senate ad-hoc Research Committee
2011-Present Experienced Resource Person for NSF Graduate Fellowship Program
2006-Present Barry Goldwater Scholarship Faculty Representative
2006-2009 Honors Development Board
College
2016-Present Strategic Directions Task Force
2012-2015 Dean's Advisory Committee
2013 Ogden College Identity Committee
2008-2011 Curriculum Committee
2004-2006 Student Awards Committee
Department
2003-Present Chemistry Advisor (average 30-40 advisees)
2015-Present Chair, Undergraduate Recruitment, Advising, and Retention
2016 Chair, Organic Chemistry Search
2011-2012 Chair, Tenure and Promotion Committee
2011-2012 Chair, Food Chemist Search
2008-2009 Chair, Biochemistry Search
2006-2012 Chair, Education Committee
2004-2006 Chemistry Club Advisor (Honorable Mention 2005, Commendable 2006)
Funding
External
NIH R15 (CA188890-01) 7/1/2015-6/30/2018 $414,320
Smith, M.E.; Williams, K.M. "Finding novel platinum(II) complex anti-cancer drugs with reduced ototoxicity".
KBRIN IDeA 5/1/2014-4/30/2015. $56,800
Smith, M.E.; Williams, K.M. "Finding novel platinum(II) complex anti-cancer drugs with reduced ototoxicity".
KSEF 7/1/2014-6/30/2015. $30,000
Smith, M.E.; Williams, K.M. "A zebrafish assay for testing ototoxicity of anti-cancer drugs".
NSF S-STEM (DUE 1259617) 8/1/2013-7/31/2018 $616,669
Williams, K.M.; Jennings, A.; Sahi, S.; Webb, C.J. "Recruitment and retention of students in biotechnology-associate majors"
NIH R15 (GM074663-01) 1/8/2007-12/31/2010 $197,450
Williams, K.M. "Reaction of bulky platinum complexes with proteins"
KY NSF EPSCoR 5/1/2005-4/30/2007 $22,824
Williams, K.M. "Ruthenium complexes as protein cleavage agents"
Research Corporation (Cottrell) 5/15/2005-5/14/2009 $29,576
Williams, K.M. "Cleavage of proteins by bulky platinum complexes"
NSF MRI (CHE 0320600) 7/1/2003-6/30/2006 $349,200
Holman, R.H.; Williams, K.M.; Pesterfield, L.; Shon, Y.-S.; Salvatore, R. "Acquisition of Nuclear Magnetic Resonance Spectrometer"
KY NSF EPSCoR 3/1/2003-12/31/2004 $25,000
Williams, K.M. "Experimental and computational studies of the competition between guanine and methionine complex formation by analogs of the anticancer drug cisplatin"
Internal
Faculty Undergraduate Student Engagement Grant (student-written proposals, $4500 awards)
2016-2018 Hruska, H.; Williams, K.M. "Improving solubility and altering reactivity of
platinum(II) anticancer compounds"
2014-2016 Duke, B.; Williams, K.M. "The effects of leaving ligands on potential anticancer
drugs"
2014-2015Gensheimer, J.; Williams, K.M. "Reaction of Platinum Anticancer Drugs
Analogs with Relevant DNA Targets"
2013-2015Whelan, C.J.; Williams, K.M. "Reaction rates of amino acids with analogs of the
anticancer drug cisplatin"
2012-2014 Hendrie, J.D.; Williams, K.M. "Synthesis, Characterization, and Reaction of an
Analog Anticancer Drug Oxaliplatin"
2012-2013 Jackson, D. C.; Williams, K.M. "The Use of Molecular Mechanics in the
Synthesis of Platinum (II) Diaminecyclohexance Compounds"
Research and Creative Activities Program
2014-2016 Williams, K.M.; Williams, B.B. "Structure-activity relationships of platinum(II)
anticancer drug analogs", $17,000.
2014-2015 Smith, M.; Williams, K.M. "Finding novel platinum(II) complex anti-cancer
drugs with reduced ototoxicity", $15,900.
2011-2012Williams, K.M. "Probing effects of bulk on reactions of platinum(II) diamine
complexes as proteins", $16,400.
Other
2010-2011Williams, K.M. "Reaction of halogenated hydrocarbons with cysteine and
DNA", WKU Summer Faculty Scholarship, 5/15/2010-5/14/2011, $6,000.
2006-2007Williams, K.M. "Untitled", Materials Characterization Center, 10/1/2006-
5/15/2007, $4,000.
2006 Williams, K.M. "Interaction of platinum complexes with peptides and proteins",
Materials Characterization Center Student Research Grant Program, 1/1/2006-
6/31/2006, $4,000.
2005-2006Williams, K.M. "Cleavage of proteins by bulky platinum complexes", Summer
Faculty Scholarship, 5/15/2005-5/14/2006, $5,000.
2005 Williams, K.M. "Cleavage of Cytochrome c by Platinum Diamine Complexes",
Materials Characterization Center Faculty Grant, 1/1/2005-6/30/2005, $5,000.
2004 Williams, K.M. "Determination of the Binding of Cisplatin Analogs t
Proteins", Materials Characterization Center Faculty Grant, 2/2/2004-
12/31/2004. $5,000.
2003-2004Williams, K.M. "DNA and Protein Complexes of Cisplatin", Western Kentucky
University Junior Faculty Fellowship, 3/13/2003-3/13/2004. $4,000.
Peer-Reviewed Publications
· Williams, K.M.; Gruner, M.; Gensheimer, J.; Wright, A.; Blair, M.; Autry, S.A.; Hammer, N.I. "Partial displacement of a triamine ligand from a platinum(II) complex after reaction with N-acetylmethionine", Inorg. Chim. Acta, 2017, 458, 163-170.
· Chityala, P.K.; Khouryieh, H.; Williams, K.; Conte, E. "Effect of xanthan/enzyme-modified guar gum mixtures on the stability of whey protein isolate stabilized fish oil-in-water emulsions", Food Chemistry, 2016, 212, 332-340.
· Khouryieh, H.; Puli, G.; Williams, K.; Aramouni, F. "Effects of xanthan-locust bean gum mixtures on the physiochemical properties and oxidative stability of whey protein stabilized oil-in-water emulsions", Food Chemistry, 2015, 167, 340-348.
· Williams, K.M.; Poynter, A.D.; Hendrie, J.D.; Jackson, D.C.; Martin, V.K. "Comparison of N-acetylmethionine reactivity between oxaliplatin and an oxaliplatin derivative with chiral (S,S) amine nitrogen atoms", Inorg. Chim. Acta, 2013, 401, 64-69.
· Williams, K.M. "An Interdisciplinary Understanding of a Disease: Project for an Honors-Embedded Biochemistry Course", in The Other Culture: Science and Mathematics Education in Honors, National Collegiate Honors Council, 2012.
· Sandlin, R.D.; Whelan, C.J.; Bradley, M.S.; Williams, K.M. "Effects of amine ligand bulk and hydrogen bonding on the rate of reaction of platinum(II) diamine complexes with key nucleotide and amin acid residues", Inorg. Chim. Acta, 2012, 391, 135-140.
· Williams, K.M.; Dudgeon, R.P.; Chmely, S.C.; Robey, S.R. "Reaction of platinum(II) diamine and triamine complexes with selenomethionine", Inorg. Chim. Acta, 2011, 368, 187-193.
· Sandlin, R.D.; Starling, M.P.; Williams, K.M. "A bulky platinum triamine complex that reacts faster with guanosine 5'-monophosphate than with N-acetylmethionine", J. Inorg. Biochem., 2010, 104, 214-216.
· Riga, A.T.; Alexander, K.S.; Williams, K. "Thermal and Oxidative Properties of Physiologically Relevant Free Fatty Acids by Dielectric Analysis and Differential Scanning Calorimetry", J. ASTM Int., 2007, 4 (3).
· Liu, L.; Wantanabe, K.; Fang, Q.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E. "Effect of Alterations of Key Active Site Residues in O6-Alkylguanine-DNA-Alkyltransferase on its Ability t Modulate the Toxicity of 1,2-Dibromoethane"; Chem. Res. Toxicol., 2007, 20, 155-163.
· Williams, K.M.; Chapman, D.J.; Massey, S.R.; Haare, C. "Interaction of N-acetylmethionine with a non-C2-symmetrical platinum diamine complex", J. Inorg. Biochem., 2005, 99, 2119-2126.
· Williams, K.M.; Rowan, C.; Mitchell, J. "Effect of Amine Ligand Bulk on the Interaction of Methionine with Platinum(II) Diamine Complexes", Inorg. Chem., 2004, 43, 1190-1196.
· Liu, L.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E. "O6-Alkylguanine-DNA Alkyltransferase has Opposing Effects in Modulating the Genotoxicity of Dibromomethane and Bromomethyl Acetate", Chem. Res. Toxicol., 2004,17, 742-752.
· Liu, L.; Hachey, D.L.; Valadez, G.; Williams, K.M.; Guengerich, F.P.; Loktionova, N.A.; Kanugula, S.; Pegg, A.E. "Characterization of a Mutagenic DNA Adduct formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase", J. Biol. Chem., 2004, 279, 4250-4259.
· Guengerich, F.P.; Williams, K.M.; Sutter, T.R.; Hayes, J.D.; Johnson, W.W.; Arneson, K.O.; Voehler, M.; Deng, Z.W.; Harris, T.M. "Competing Reactions of Aflatoxin B1 Dialdehyde: Enzymatic Reduction vs. Adduction with Lysine", ACS Sym. Ser., 2004, 865, 171-182.
· Liu, L.; Pegg, A.E.; Williams, K.M.; Guengerich, F.P. "Paradoxical Enhancement of the Toxicity of 1,2-dibromoethane by O6-Alkylguanine-DNA Alkyltransferase", J. Biol. Chem., 2002, 277, 37920-37928.
· Guengerich, F.P.; Voehler, M.; Williams, K.M.; Deng, Z.; Harris, T.M. "Structure of the Aflatoxin B1 Dialdehyde Adduct Formed from Reaction with Methylamine", Chem. Res. Toxicol., 2002, 15, 793-798.
· Guengerich, F.P.; Arneson, K.O.; Williams, K.M.; Deng, Z.; Harris, T.M. "Reaction of Aflatoxin B1 Oxidation Products with Lysine", Chem. Res. Toxicol., 2002, 15, 780-792.
· Nakamura, K.; Hanna, I.H.; Cai, H.; Nishimura, Y.; Williams, K.M.; Guengerich, F.P. "Coumarin Substrates for Cytochrome P450 2D6 Fluorescence Assays", Anal. Biochem., 2001, 292, 280-286.
· Williams, K.M.; Scarcia, T.; Natile, G.; Marzilli, L.G. "Imprinting Structural Information from a GpG Ligand into the Configuration of a Chiral Diamine Ligand through Second-Sphere Communication in Platinum(II) Complexes" Inorg. Chem., 2001, 40, 445-454.
· Williams, K.M.; Cerasino, L.; Natile, G.; Marzilli, L.G. "cis-Pt(NH3)2(GpG) Properties Interpreted through Comparison with Retro-Model GpG Adducts Having Carrier Ligands Designed to Slow Dynamic Motion". J. Am. Chem. Soc., 2000, 122, 8021-8030.
· Sunderam, V.; Cheung, S.Y.; Chodrow, S.; Gray, P.; Grigni, M.; Hirsch, M.; Hutto, P.; Krantz, A.; Olesen, S.; Rhee, I.; Goddard, T.; Sult, J.; Migliardi, M.; Marzilli, L.; Ano, S.; Williams, K.; Sullivan, S. "CCF: A Framework for Collaborative Computing". IEEE Internet Comput., 2000, 4, 16-24.
· Williams, K.M.; Cerasino, L.; Intini, F.P.; Natile, G.; Marzilli, L.G. "Effects of Six-Membered Ring Conformation on the Rotamer Distribution and Rate of Atropisomerization in Platinum(II)-Guanine Compounds: 2,4-Bis(methylamino)pentane Complexes". Inorg. Chem., 1998, 37, 5260-5268.
· Cerasino, L.; Williams, K.M.; Intini, F.P.; Cini, R.; Marzilli, L.G.; Natile, G. "Factors Influencing the Configuration and Conformation of Diamine Chelate Rings in Platinum(II) Compounds: 2,4-Bis(methylamino)pentane Complexes". Inorg. Chem., 1997, 36, 6070-6079.
Theses
Graduate
· Smith, Adam. "The Effects of Carrier Ligands on Cisplatin Binding to Cysteine and Methionine", 2017
· Puckett, Nathan. "Effects of Binding Affinity between Bovine Serum Albumin and Platinum Drugs", 2017
· Sehgal, Rippa. "Binding of Oxaliplatin and its Analogs with DNA Nucleotides at Variable pH and Concentration Levels", 2016
· Koli, Ramya, "Effect of Leaving Ligands of Platinum(II) Diamine Complexes on DNA and Protein Residues", 2013
· Nandala, Swathi, "Effects of Cisplatin Analog Size on the Reaction with DNA Bases", 2013
· Robey, Stephanie, "Reactions of Platinum(II) Compounds with Selenium Containing Amino Acids", 2013
· Rapolu, Chaitanya, "Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes", 2011
· Ravipati, Dhatri, "Activity of Analogs of Anticancer Drugs on the Serine Protease Enzymes Subtilisin and Chymotrypsin", 2011
· Liao, Yueh-Ying, "The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives", 2010
· Muneeruddin, Khaja, "High Pressure Liquid Chromatography Studies of the Reaction of Platinum Complexes with Peptides", 2010
· Kotadia, Nayna, "A Study on the Protein Interaction with Different Platinum Compounds", 2008
Undergraduate
· Marcum, Sam, "Synthesizing cisplatin compounds that preferentially bind N-acetyl-L-methionine and guanosine monophosphate", 2017
· Duke, Brooke, "Toxicity of platinum containing compounds with variable leaving ligands on cancer cells", 2016
· Tope, Cynthia, "Relative reaction rates of the amino acids cysteine, methionine, and histidine with analogs of the anti-cancer drug cisplatin", 2015
· Mann, Kyle, "The interaction of glutathione with platinum and the role of pH in altering ligand formation between platinum and N-acetylcysteine", 2015
· Whelan, Celia, "Reaction rates of amino acids with derivatives of the anticancer drug cisplatin", 2014
· Gruner, Morgan, "Synthesis and reactivity of a platinum triamine complex", 2014
· Hendrie, Jonathan, "Synthesis and reactivity with methionine of an analog of the anticancer drug oxaliplatin", 2013
· Jackson, Daniel, "Computational and experimental studies of oxaliplatin derivatives", 2013
· Morgan, Brittany, "Reaction of Halogenated Hydrocarbons with Cysteine and Nucleotides", 2012
· Poynter, Amy, "Oxaliplatin and Oxaliplatin Derivatives: Synthesis, Characterization, and Reactivity with Biologically Relevant Ligands", 2012
· Sahi, Nilesh, "The Reaction of Methionine with a Non-C2-Symmetrical Platinum (II) Diamine Compound", 2012
· Robey, Stephanie, "Reactions With Platinum(II) Complexes And Selenium-Containing Amino Acids", 2011
· Turner, Emily, "Modeling enzyme thiolate chemistry with cysteine", 2009
· Lively, Rebekkah, "Reaction of platinum complexes with selenomethionine", 2009
· Chapman, Donald, "Molecular Mechanics Analysis of Platinum Compounds Chelated to Methionine Residues", 2006
Presentations and Abstracts
· Owens, C.; Khouryieh, J.; Williams, K. "Effect of pH and xanthan-locust bean mixtures on the physiochemical properties of whey protein-stabilized oil-in-water emulsions", WKU Student Research Conference, 2016.
· Duke, B.; Williams, B.; Williams, K. "Effects of leaving ligands on prospective anticancer compounds", WKU Student Research Conference, 2016.
· Wright, A.; Williams, K. "Partial displacement of a triamine ligand from platinum(II) by guanosine 5’-monophosphate", WKU Student Research Conference, 2016.
· Sehgal, R.; Williams, K. "Reactions of Oxaliplatin and Its Analog with DNA Nucleotides at Variable pH and Concentration Levels", WKU Student Research Conference, 2016.
· Owens, C.; Khouryieh, J.; Williams, K. "Effect of pH and xanthan-locust bean mixtures on the physiochemical properties of whey protein-stabilized oil-in-water emulsions", Annual American Chemical Society Meeting, San Diego, CA, 2016.
· Duke, B.; Williams, B.; Williams, K. "Effects of leaving ligands on prospective anticancer compounds", Annual American Chemical Society Meeting, San Diego, CA, 2016.
· Wright, A.; Williams, K. "Partial displacement of a triamine ligand from platinum(II) by guanosine 5’-monophosphate", Annual American Chemical Society Meeting, San Diego, CA, 2016.
· Duke, B.; Williams, B.; Williams, K. "Effects of leaving ligands on prospective anticancer compounds", Kentucky Academy of Science Annual Meeting, 2015.
· Sehgal, R.; Williams, K. "Reactions of Oxaliplatin and Its Analog with DNA Nucleotides at Variable pH and Concentration Levels", NIH INBRE Conference, Biloxi, MS, 2015.
· Mann, K.; Williams, K. "Glutathione's interaction with platinum, and the role of pH in alterning ligand formation between N-acetylcysteine and platinum"; WKU Student Research Conference, 2015.
· Tope, C.; Williams, K. "Reaction rates of the amino acids cysteine, methionine, and histidine with analogs of the anticancer drug cisplatin"; WKU Student Research Conference, 2015.
· Wright, A.; Blair, M.; Williams, K. "Reaction of platinum complexes with a methionine analog"; WKU Student Research Conference, 2015.
· Sehgal, R.; Williams, K. "Reactions of oxaliplatin analogs with DNA nucleotides"; WKU Student Research Conference, 2015.
· Duke, B.; Williams, B.; Williams, K. "The Effects of Leaving Ligands on Potential Anticancer Drugs"; WKU Student Research Conference, 2015.
· Gensheimer, J.L..; Williams, K. "Unusual reactivity of a platinum(II) triamine complex"; WKU Student Research Conference, 2015.
· Gensheimer, J.L.; Williams, K.M. "Reaction of platinum(II) diamine and triamine complexes with adenosine 5'-monophosphate", 248th Annual American Chemical Society Meeting, San Francisco, CA, 2014.
· Whelan, C.J.; Williams, K.M. "Reaction rates of amino acids with derivatives of the anticancer drug cisplatin", 248th Annual American Chemical Society Meeting, San Francisco, CA, 2014.
· Gensheimer, J.L.; Williams, K.M. "Reaction of platinum(II) diamine and triamine complexes with adenosine 5'-monophosphate", Southeastern Regional Meeting of the American Chemical Society, Nashville, TN, 2014.
· Gruner, M.; Williams, K.M. "The Reaction of a Platinum Triamine Complex with Different DNA and Protein Complexes", WKU Student Research Conference, Bowling Green, KY, 2014.
· Mahmood, M.S.; Williams, K.M. "The Reaction Rates Of Chemotherapy Drugs With Protein And DNA", WKU Student Research Conference, Bowling Green, KY, 2014.
· Tope, C.; Williams, K.M. "Reaction Rates of the Amino Acids Cysteine, Methionine, and Histidine with Analogs of the Anticancer Drug Cisplatin", WKU Student Research Conference, Bowling Green, KY, 2014.
· Whelan, C.J.; Williams, K.M. "Reaction Rates of Amino Acids with Derivatives of the Anticancer Drug Cisplatin", WKU Student Research Conference, Bowling Green, KY, 2014.
· Williams, K.M. "Tailoring Platinum(II) Complexes to Biologically Relevant Targets", University of Louisville Seminar, Louisville, KY, 2014.
· Williams, K.M. "Tailoring Platinum(II) Complexes to Biologically Relevant Targets", University of Alabama at Huntsville Seminar, Huntsville, AL, 2013.
· Williams, K.M. "Tailoring Platinum(II) Complexes to Biologically Relevant Targets", Campbellsville University Seminar, Campbellsville, KY, 2013.
· Whelan, C.J.; Williams, K.M. "Reaction rates of amino acids with analogs of the anticancer drug cisplatin", American Chemical Society National Meeting, ACS, Indianapolis, IN, 2013.
· Hendrie, J.D.; Williams, K.M. "Characterization and reaction of an analog anticancer drug oxaliplatin", American Chemical Society National Meeting, ACS, Indianapolis, IN, 2013.
· Jackson, D.C.; Williams, K.M. "Molecular mechanics of oxaliplatin and oxaliplatin and dien derivatives with their relevant biological targets", American Chemical Society National Meeting, ACS, Indianapolis, IN, 2013.
· Tope, C.; Williams, K.M. "Reaction rates of cysteine, methionine, and histidine with analogs of cisplatin", American Chemical Society National Meeting, ACS, Indianapolis, IN, 2013.
· Hendrie, J.D.; Williams, K.M. "Synthesis, characterization, and reaction of an analog anticancer drug oxaliplatin", American Chemical Society National Meeting, ACS, New Orleans, LA, 2013.
· Whelan, C.J.; Williams, K.M. "Reaction rates of amino acids with analogs of the anticancer drug cisplatin", American Chemical Society National Meeting, ACS, New Orleans, LA, 2013.
· Hendrie, J.D., Williams, K.M. "Characterization and Reaction of an Analog Anticancer Drug Oxaliplatin", WKU Student Research Conference, Bowling Green, KY, 2013.
· Jackson, D.C.; Williams, K.M. "Molecular Mechanics of Oxaliplatin Derivatives with Their Relevant Biological Targets", WKU Student Research Conference, Bowling Green, KY, 2013.
· Whelan, C.J., Williams, K.M. "Reaction Rates of Amino Acids with Analogs of the Anticancer Drug Cisplatin", WKU Student Research Conference, Bowling Green, KY, 2013.
· Tope, C.; Williams, K.M. "Reactions of the Amin Acids Cysteine, Methionine, and Histidine with Analogs of the Anticancer Drug Cisplatin", WKU Student Research Conference, Bowling Green, KY, 2013.
· Puli, G.; Williams, K.M.; Khouryieh, H.A. "Synergistic Stabilization of Oil-in-Water Emulsions Containing Mixtures of Xanthan and Locust Bean Gums", WKU Student Research Conference, Bowling Green, KY, 2013.
· Williams, K.M. "Tailoring Platinum(II) Complexes to Biologically Relevant Targets", Indiana State Seminar, Terra Haute, IN, 2013.
· Whelan, C.J.; Williams, K.M. "Reaction rates of amino acids with analogs of the anticancer drug cisplatin", 243rd Annual American Chemical Society Meeting, San Diego, CA, 2012.
· Poynter, A.D.; Martin, V.K.; Williams, K.M. "Reactivity of oxaliplatin and derivatives with biologically relevant ligands", 243rd Annual American Chemical Society Meeting, San Diego, CA, 2012.
· Martin, V.K.; Poynter, A.D.; Williams, K.M. "Synthesis, purification, and characterization of derivatives of the anticancer drug oxaliplatin", 243rd Annual American Chemical Society Meeting, San Diego, CA, 2012.
· Nandala, S.; Williams, K.M. "Bulk Effects of Cisplatin Analogs on DNA Bases", 42nd Annual Student Research Conference, Bowling Green, KY, 2012.
· Koli, R.; Williams, K.M. "Effect of Leaving Ligands of Platinum Complexes on Guanine Residue of DNA and Methionine Protein Residue", 42nd Annual Student Research Conference, Bowling Green, KY, 2012.
· Tope, C.; Williams, K.M. "Reactivity of oxaliplatin and derivatives with biologically relevant ligands", 42nd Annual Student Research Conference, Bowling Green, KY, 2012.
· Poynter, A.D.; Williams, K.M. "Reactivity of oxaliplatin and derivatives with biologically relevant ligands", 97th Annual Kentucky Academy of Science Meeting, Murray, KY, 2011.
· Martin, V.K.; Williams, K.M. "Synthesis, purification, and characterization of analogs of the anticancer drug oxaliplatin", 97th Annual Kentucky Academy of Science Meeting, Murray, KY, 2011.
· Morgan, B.S.; Williams, K.M. "The Reaction of Halogenated Hydrocarbons with Cysteine and DNA", 97th Annual Kentucky Academy of Science Meeting, Murray, KY, 2011.
· Morgan, B.S.; Williams, K.M. "Reaction of halogenated hydrocarbons with cysteine and nucleotides", 241st Annual American Chemical Society Meeting, Anaheim, CA, 2011.
· Robey, S.R.; Williams, K.M. "Reaction of platinum(II) diamine complexes with selenium-containing amino acids", 241st Annual American Chemical Society Meeting, Anaheim, CA, 2011.
· Ravipati, D.; Williams, K.M. "Inhibition of Subtilisin by Analogs of the Anticancer Drug Cisplatin", 41st Annual Student Research Conference (WKU), 2011.
· Rapolu, C.; Williams, K.M. "Inhibition of the Enzyme Papain by Analogs of the Anticancer Drug Cisplatin", 41st Annual Student Research Conference (WKU), 2011.
· Whelan, C.; Williams, K.M. "Reaction Rates of Amino Acids with Analogs of the Anticancer Drug Cisplatin", 41st Annual Student Research Conference (WKU), 2011.
· Martin, V.; Poynter, A.; Williams, K.M. "Synthesis and Characterization of Analogs of the Anticancer Drug Oxaliplatin", 41st Annual Student Research Conference (WKU), 2011.
· Morgan, B.S.; Williams, K.M. "Reaction of halogenated hydrocarbons with cysteine and nucleotides", 30th Annual Undergraduate Research Conference, University of Memphis, 2011.
· Robey, S.R.; Williams, K.M. "Reaction of platinum(II) diamine complexes with selenium-containing amino acids", 30th Annual Undergraduate Research Conference, University of Memphis, 2011.
· Sahi, N.; Williams, K.M. "Reaction of methionine with a non-C2-symmetrical platinum(II) diamine compound", 96th Annual Kentucky Academy of Science Meeting, 2010.
· Robey, S.R.; Williams, K.M. "Reaction of platinum(II) diamine complexes with selenium-containing amino acids", 96th Annual Kentucky Academy of Science Meeting, 2010.
· Sahi, N.; Williams, K.M. "Reaction of methionine with a non-C2-symmetrical platinum(II) diamine compound", 239th Annual National American Chemical Society Meeting, 2010.
· Muneeruddin, K.; Williams, K.M. "Reaction of platinum(II) complexes with peptides", 239th Annual National American Chemical Society Meeting, 2010.
· Muneeruddin, K.; Williams, K.M. "Reaction of platinum(II) complexes with peptides", 40th Annual Student Research Conference (WKU), 2010.
· Muneeruddin, K.; Williams, K.M. "Reaction of platinum(II) complexes with peptides", 95th Annual Kentucky Academy of Science Meeting, 2009.
· Starling, M.P.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 237th Annual American Chemical Society Meeting; 2009.
· Lively, R.; Williams, K.M. "Characterization of products between cisplatin analogs and selenomethionine". 237th Annual American Chemical Society Meeting; 2009.
· Starling, M.P.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 29th Annual Student Research Conference (University of Memphis); 2009.
· Starling, M.P.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 39th Annual Student Research Conference (WKU); 2009.
· Sahi, N.; Williams K.M. "Reaction of Methionine with a Non-C2-Symmetrical Platinum(II) Diamine Compound". Kentucky Honors Roundtable; 2009.
· Turner, E.M.; Williams, K.M. "Modeling Thiolate Enzyme Chemistry with Cysteine at High pH". 60th Southeastern Regional Meeting of the American Chemical Society; 2008.
· Starling, M.P.; Sandlin, B.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 60th Southeastern Regional Meeting of the American Chemical Society; 2008.
· Lively, R.; Chmley, S.C.; Williams, K.M. "Reaction of Cisplatin Analogs with Selenomethionine". 60th Southeastern Regional Meeting of the American Chemical Society; 2008.
· Sahi, N.; Williams, K.M. " Reaction of Methionine with a Non-C2-Symmetrical Platinum(II) Diamine Compound". 60th Southeastern Regional Meeting of the American Chemical Society; 2008.
· Starling, M.P.; Sandlin, B.; Williams, K.M. "Reaction of a Bulky Platinum Triamine Complex with Guanine and Methionine". 94th annual Kentucky Academy of Science Meeting; 2008.
· Liao, Y.Y.; Williams, K.M. "Reaction of methionine derivatives with a platinum(II) diamine compound". 94th annual Kentucky Academy of Science Meeting; 2008.
· Sahi, N.; Williams, K.M. " Reaction of Methionine with a Non-C2-Symmetrical Platinum(II) Diamine Compound". 94th annual Kentucky Academy of Science Meeting; 2008.
· Williams, K.M. "Effects of Size and Shape of Cisplatin Analogs on the Reactions with DNA and Protein Targets". Invited seminar, University of Memphis Department of Chemistry; 2008
· Williams, K.M. "Using controversies to promote critical thinking in the sciences". Kentucky Conference on the Scholarship of Teaching and Learning, Lexington, KY; 2008.
· Lively, R.; Chmley, S.C.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 38th annual student research conference, Bowling Green, KY; 2008.
· Lively, R.; Chmley, S.C.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 235th Annual American Chemical Society Meeting, New Orleans, LA; 2008.
· Williams, K.M. "Use of a wiki to enhance group projects". 235th Annual American Chemical Society Meeting, New Orleans, LA; 2008.
· Lively, R.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 93rd Annual Kentucky Academy of Science Meeting, Louisville, KY; 2007.
· Lively, R.; Williams, K.M. "Reaction of cisplatin analogs with selenomethionine". 37th annual student research conference, Bowling Green, KY; 2007.
· Sandlin, B.M.; Williams, K.M. "Factors affecting the rate of reaction of platinum anticancer drug models with DNA and protein targets". 37th annual student research conference, Bowling Green, KY; 2007.
· Gibson, S.C.; Williams, K.M. "Reduction of ruthenium(III) complexes t promote reaction with proteins". 233rd Annual American Chemical Society Meeting, Chicago, IL; 2007.
· Sandlin, B.M.; Williams, K.M. "Factors affecting the rate of reaction of platinum(II) complexes with DNA and protein targets". 233rd Annual American Chemical Society Meeting, Chicago, IL; 2007.
· Gibson, S.C.; Williams, K.M. "Reduction of ruthenium(III) complexes t promote reaction with proteins". 92nd Annual Kentucky Academy of Science Meeting, Morehead, KY; 2006.
· Sandlin, B.M.; Williams, K.M. "Factors affecting the rate of reaction of platinum(II) complexes with DNA and protein targets". 92nd Annual Kentucky Academy of Science Meeting, Morehead, KY; 2006. Davis, B.M.; Williams, K.M. "Effects of amine ligand bulk on the rate of reaction of platinum(II) diamine complexes with guanine and methionine residues." 36th annual student research conference, Bowling Green, KY; 2006.
· Chapman, D.J.; Williams, K.M. "NMR studies of the reaction of platinum complexes with a peptide." 36th annual student research conference, Bowling Green, KY; 2006.
· Chmely, S.C.; Williams, K.M. "Reaction of Selenomethionine with Platinum Complexes." 36th annual student research conference, Bowling Green, KY; 2006.
· Davis, B.M.; Williams, K.M. "Effects of amine ligand bulk on the rate of reaction of platinum(II) diamine complexes with guanine and methionine residues." 231st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
· Bragg, S.A.; Hobbs, A.M.; Pesterfield, L.L; Williams, K.M. "Combining chemistry activities with service opportunities in a Student Affiliate chapter." 231st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
· Chapman, D.J.; Williams, K.M. "Molecular Mechanics Predictions, Verifications, and Trends for N-acetylmethionine Reactions with Bulky Platinum Compounds." 231st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
· Chmely, S.C.; Williams, K.M. "Reaction of Selenomethionine with Platinum Complexes." 231st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
· Alicie, B.; Moore, A.; Williams, K.M. "Reaction of ruthenium(III) complexes with heterocyclic ligands and glutathione." 231st Annual American Chemical Society Meeting, Atlanta, GA; 2006.
· Davis, B. M.; Williams, K.M. "Effects of amine ligand bulk on the rate of reaction of platinum(II) diamine complexes with guanine and methionine residues." 91st Annual Kentucky Academy of Science Meeting, Richmond, KY; 2005.
· Alicie, B.; Moore, A.; Williams, K.M. "Reaction of Ruthenium(III) Complexes with Heterocyclic Ligands and Glutathione". 91st Annual Kentucky Academy of Science Meeting, Richmond, KY; 2005.
· Chmely, S.C.; Williams, K.M. "Interaction of platinum complexes with selenomethionine". 57th Annual Southeast Regional Meeting of the American Chemical Society, Memphis, TN; 2005.
· Williams, K.M. "Platinum in Biochemistry: From Cancer Drugs t Protein Cleavage", Departmental Seminar, Western Kentucky University, 2005.
· Davis, B.; Bradley, M.S.; Lam, A.P.; Williams, K.M. "Effects of amine ligand bulk in platinum diamine complexes on the rate of reaction with DNA and protein residues". 35th annual student research conference, Bowling Green, KY; 2005.
· Massey, S.R.; Williams, K.M. "Reaction of N-acetylmethionine with a non-C2-symmetrical platinum diamine complex". 35th annual student research conference, Bowling Green, KY; 2005.
· Davis, B.; Bradley, M.S.; Lam, A.P.; Williams, K.M. "Effects of amine ligand bulk in platinum diamine complexes on the rate of reaction with DNA and protein residues". 229th Annual American Chemical Society Meeting, San Diego, CA, 2005.
· Milner, K.; Hobbs, A.M.; Culver, J.P.; Williams, K.M. "Western Kentucky University Student Affiliate Chapter". 229th Annual American Chemical Society Meeting, San Diego, CA, 2005.
· Massey, S.R.; Williams, K.M. "Reaction of N-acetylmethionine with a non-C2-symmetrical platinum diamine complex". 229th Annual American Chemical Society Meeting, San Diego, CA, 2005.
· Chapman, D.J.; Williams, K.M. "Molecular mechanics analysis of platinum complexes with methionine residues". 229th Annual American Chemical Society Meeting, San Diego, CA, 2005.
· Chapman, D.J.; Rowan, C.; Williams, K.M. "Molecular mechanics analysis of bulky platinum complexes with DNA and protein residues". 56th Annual Southeast Regional Meeting of the American Chemical Society, Raleigh, NC, 2004.
· Massey, S.R.; Williams, K.M. "Reaction of methionine with bulky platinum diamine complexes". 56th Annual Southeast Regional Meeting of the American Chemical Society, Raleigh, NC, 2004.
· Davis, B.; Bradley, M.S.; Lam, A.P.; Williams, K.M. "Effects of Amine Ligand Bulk on the Rate of Reaction with DNA and Protein Residues by Platinum Complexes". 90th Annual Kentucky Academy of Science Meeting, Murray, KY, 2004.
· Chapman, D.J.; Rowan, C.; Williams, K.M. "Molecular mechanics analysis of bulky platinum complexes with DNA and protein residues". 90th Annual Kentucky Academy of Science Meeting, Murray, KY, 2004.
· Massey, S.R.; Rowan, C.; Williams, K.M. "Reaction of methionine with bulky platinum diamine complexes". 90th Annual Kentucky Academy of Science Meeting, Murray, KY, 2004.
· Whitely, N.R.; Riga, A.T.; Clauson, M.; Williams, K.M.; Pan, W.-P. "Qualitative Detection of Biological Species Using Electrochemical Methods". The 32nd Annual Conference on Thermal Analysis and Applications, Williamsburg, VA 2004.
· Pan, W.-P.; Riga, A.T.; Williams, K.; Whitely, N. "Calorimetric and Dielectric Properties of Physiologically Relevant Fatty Acids". The 13th International Congress on Thermal Analysis and Calorimetry, Sardinia, Italy, 2004.
· Gollapudi, K.; Williams, K.M. "Determination of the Binding of Cisplatin Analogs t Proteins". 10th Annual Kentucky EPSCoR Conference, Lexington, KY; 2004.
· Whitely, N.; Clauson, M.; Williams, K.; Pan, W.-P. "Novel Detection of Biological Species using Dielectric Analysis". 34th annual student research conference, Bowling Green, KY; 2004.
· Gollapudi, K.; Williams, K.M. "Determination of the Binding of Cisplatin Analogs t Proteins". 34th annual student research conference, Bowling Green, KY; 2004.
· Bradley, M.S.; Williams, K.M. "Effects of Amine Ligand Bulk on the Rate of Reaction with DNA and Protein Residues by Platinum Complexes". 34th annual student research conference, Bowling Green, KY; 2004.
· Gollapudi, K.; Rowan, C.; Williams, K.M. "Model DNA and Protein Adducts formed with a Bulky Platinum Diamine Complex". 89th Annual Kentucky Academy of Sciences Meeting, Bowling Green, KY; 2003.
· Bradley, M.S.; Williams, K.M. "Effects of Amine Ligand Bulk on the Rate of Reaction with DNA and Protein Residues by Platinum Complexes". 89th Annual Kentucky Academy of Sciences Meeting, Bowling Green, KY; 2003.
· Williams, K.M. "Analogs of the Anticancer Drug Cisplatin and their Interactions with DNA and Protein Targets". Departmental Seminar, Western Kentucky University, 2003.
· Williams, K.M. "Computational and Experimental Studies of the Interaction of Cisplatin Analogs with Methionine". Invited Seminar, Murray State University Department of Chemistry; 2003.
· Williams, K.M.; Rowan, C.; Mitchell, J. "Experimental and Computational Studies of the Competition between DNA and Protein Complex Formation by Platinum Anticancer Compounds". 9th Annual Kentucky EPSCoR Conference, Lexington, KY; 2003.
· Williams, K.M.; Liu, L.; Pegg, A.E.; Guengerich, F.P. "Enhancement of Toxic and Mutagenic Effects of Ethylene Dibromide by Alkylguanine-DNA Alkyltransferase". The 224th Annual American Chemical Society Meeting, Boston, MA; 2002.
· Guengerich, F.P.; Voehler, M.; Williams, K.M.; Arneson, K.O.; Deng, Z.; Harris, T.M. "A protein adduct formed from the reaction of a dialdehyde derivative of aflatoxin B1 with BSA". The 224th Annual American Chemical Society Meeting, Boston, MA; 2002.
· Guengerich, F.P.; Voehler, M.; Williams, K.M.; Arneson, K.O.; Deng, Z.; Harris, T.M. "Reaction of Aflatoxin B1 Oxidation Products with Lysine". The 224th Annual American Chemical Society Meeting, Boston, MA; 2002.
· Williams, K.M.; Liu, L.; Pegg, A.E.; Guengerich, F.P. "Mass Spectrometry Studies of Oligonucleotides Cross-Linked to Alkylguanine Transferase via Ethylene Dibromide". The 41st Annual Society of Toxicology Meeting, Nashville, TN; 2002, 1716.
· Guengerich, F.P.; Arneson, K.O.; Williams, K.M.; Deng, Z.; Harris, T.M. "Reaction of Aflatoxin B1 Oxidation Products with Lysine and Proteins". 93rd Annual American Association for Cancer Research Meeting, San Francisco, CA; 2002.
· Marzilli, L.G.; Williams, K.; Sullivan, S.; Marzilli, P.; Saad, J.; Kuklenyik, Z.; Ano, S.; Fannizi, F.; Natile, G. "Retro-modeling in Pt anticancer drug chemistry aided by MM methods". The 219th Annual American Chemical Society Meeting, San Francisco, CA; 2000.
· Marzilli, L.G.; Williams, K.; Sullivan, S.; Villanueva, J.; Ano, S. O.; Marzilli, P.; Saad, J.; Ciccarese, A.; Intini, F.; Fannizi, F.; Natile, G. "Retro-modeling in Pt anticancer drug chemistry". The 9th International Conference on Biological Inorganic Chemistry (ICBIC), Minneapolis, MN; 1999.